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However, when the -carbon (the carbon adjacent to the nitrogen) in backbone-extended amino acids is replaced with oxygen, a more rigid conformation is observed (Figure a)

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This is clinically significant because metabolic dysfunction-associated steatotic liver disease (MASLD) previously known as non-alcoholic fatty liver disease (NAFLD) is estimated to affect approximately 2530% of adults in the UK (British Liver Trust), and can progress to cirrhosis and liver failure if untreated